Novel Radioligands for Pet Imaging and Phenotyping of Multiple Sclerosis Diagnosis

Grant number: 1142814 | Funding period: 2018 - 2020

Completed

Abstract

This project aims to catalyse a paradigm shift in the management of multiple sclerosis (MS). We will achieve this paradigm shift by developing radioligands that can be used to image the brain of MS patients. These agents will target a protein in MS patients that will be diagnostic of the state of disease progression. This will facilitate prediction of disease outcome, monitoring of therapeutic response and the development of novel treatment strategies for the better treatment of MS.

Related publications (2)

Fluorinated pyrimidine 5-carboxamides as potential tools for MERTK targeted fluorine-18-PET-radioligand development

R Mudududdla, SW Wong, N Nguyen, L Xue, MA Stashko, X Wang, L Vivash, MD Binder, U Ackermann, YE Bozikis, TJ Kilpatrick, JB Baell

2026-01-01

MER tyrosine kinase (MERTK) is highly expressed on the protective and reparative phenotype of microglia, which is in response to n..

Development of [18F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease

SW Wong, L Vivash, R Mudududdla, N Nguyen, SJ Hermans, DM Shackleford, J Field, L Xue, A Aprico, NC Hancock, M Haskali, MA Stashko, SV Frye, X Wang, MD Binder, U Ackermann, MW Parker, TJ Kilpatrick, JB Baell

2021-12-15

MER tyrosine kinase (MERTK) upregulation is associated with M2 polarization of microglia, which plays a vital role in neuroregener..

University of Melbourne Researchers

Trevor Kilpatrick